PseudoGenes. [wikipedia]
Two 2008 publications in Nature discuss that some endogenous siRNAs are derived from pseudogenes, and thus some pseudogenes play a role in regulating protein-coding transcripts.[30][31] In June 2010, Nature published an article showing the mRNA levels of tumour suppressor PTEN and oncogenic KRAS is affected by their pseudogenes PTENP1 and KRAS1P.
This discovery demonstrated an miRNA decoy function for pseudogenes and identified their transcripts as biologically active units in tumor biology; thus attributing a novel biological role to expressed pseudogenes, as they can regulate coding gene expression, and reveal a non-coding function for mRNAs in disease progression.
Be Clear! on Cancer
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